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Faculty and Staff » Shigetoshi Eda

Shigetoshi Eda


Shigetoshi Eda is a Professor in the Department of Forestry, Wildlife & Fisheries. He is also appointed as Associate Director of Center for Wildlife Health-ORU, Adjunct Associate Professor at the Department of Microbiology, Senior Personnel at the National Insitute for Mathematical & Biological Synthesis. He received Ph.D. degree from Tokyo University of Pharmacy and Life Science (Japan). After working as a postdoctoral researcher at the University of California Riverside, he joined the university in 2003.

He is studying immunological reactions of cattle against surface molecules of Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in livestock and wild animals. With Dr. Speer, Cathy Scott and graduate students, he developed a highly accurate diagnostic test for the disease and the research on Johne's disease diagnosis resulted in several scientific publications, three patents, and several extramural grants & contracts. The diagnostic test was licensed to a veterinary diagnostic company and commercialized in February 2015. Also, in collaboration with Dr. Jayne Wu in the Department of Electrical Engineering and Computer Science, he is develpoing an on-site diagnostic device for infectious diseases based on alternating current electrokinetic (ACEK)-based capacitance sensing. This technology was licensed to a private company in August 2014. His other research interest include mathematical modeling of infectious disease epidemiology and immunology. With Dr. Eiichi Momotani (Toho Medical University) and Dr. Kurosu Michio (University of Tennesee Memphis), he is studing potential roles of MAP molecules in Crohn's disease.

Recent publications (total 49 as of July 2015)
(* corresponding author, $ student/staff mentored)

1. A. Koets*, S. Eda, and S. Sreevatsan, 2015, The with-in host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter, Veterinary Research, 46:61

2. M. Martcheva*, S. Lenhart, S. Eda, D. Klinkenberg, E. Momotani, and J. Stabel, 2015, An Immuno-Epidemiological Model for Johne's Disease in Cattle, Veterinary Research, 46:69

3. Robins$, S. Bogen$, A. Francis$, A. Westhoek$, A. Kanarek, S. Lenhart and S. Eda*, 2015, Agent-based model for Johne's disease dynamics in a dairy herd, To be submitted to Veterinary Research, 46:68

4. B. L. Joyce$, S. Eda, J. Dunlap, C. Stewart*, 2015, Morphology and ploidy level determination of Pteris vittata callus during induction and regeneration, BMC Biotechnology, 14(1):96.

5. S. Li$, Y. Ren, H. Cui$, J. Wu, S. Eda and H. Jiang, 2015, Alternating current electrokinetics enhanced in-situ capacitive immunoassay, Electrophoresis, 36(3):471-474

6. A. Wadhwa$, R. E. Johonson$, K. Eda$, W. R. Waters, M. V. Palmer, J. P. Bannantine, S. Eda*, 2014, Evaluation of ethanol vortex ELISA for detection of bovine tuberculosis in cattle and deer. BMC Vet Res. 10:147

7. G. Magombedze$, S. Eda,V. V. Ganusov, 2014, Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobaterium avium subspecies paratuberulosis infection in ruminants. PLoS Comput Biol. (IF:4.867) e1003414

8. S. Li$, H. Cui$, J. Wu, K. Yang$, A. Wadhwa$, S. Eda, and H. Jiang. 2014. AC electrokinetics-enhanced capacitive immunosensor for point-of-care serodiagnosis of infectious diseases., Biosensors and Bioelectronics. 51:437-443

List of pulicaitons in PubMed

Computer skills

A computer programming language, Perl, has been used extensively in Bioinformatics. Using the language, he wrote many computer programs for his research. One of the programs is for organizing scientific PDF files and has been downloaded by, at least, 500 people more information). Also, he wrote computer programs for amino acid sequence alignment, phylogenic tree analysis, biostatistics, machine learning methods/artificial intelligence, and mathematical modeling of infectious diseases (available online). He is also familiar with other programming languages, such as Java and C++. Using (D,X)HTML, CSS, XML, XSLT, Ajax, and Perl/CGI, he created the official website of the Plant Biotechnology Building and Genomics hub at the University of Tennessee Knoxville and have served as a webmaster of the page for four years. He is using statistical software R and agent-based model software (NetLogo) for his research in mathematical modeling of infectious disease epidemiology and immunology.

Border Photo

Contact Information

Shigetoshi Eda
366 Plant Biotechnology Bldg
(865) 974-5008
Email: seda[at]

Past graduate student
Ashutosh Wadhwa, Ph.D., Postdoc in CDC