AS 483

Lecture 12

Swine Genetics

 

 

Modern swine have 19 pairs of chromosomes

  • As with all animals and plants, each chromosome contains thousands of genes

  • It is estimated that each breeder (sow or boar) contributes over 1 billion gene combinations to a single offspring

  • When combined with the second mate the result is 1 billion x 1 billion genetic combinations (individual pigs)
  •  


    Simple Gene Inheritance

  • Simple gene inheritance is exemplified by traits that are controlled by single gene pairs

  • Simple gene inheritance allowed Mendel to theorize that inheriance was the result of finite pieces of genetic material

  • Examples in swine = blood type, eye color, hair color, erect or lop ears
  •  

    Multiple Gene Inheritance

  • Most characteristics are the result of multiple gene pairs

  • These traits include most economically important traits such as performance traits, mothering ability, etc.

  • The mechanisms of gene segregation in meiosis still apply with multiple gene inheritance, however the result is much more complicated

  • This type of inheritance results in a much more complex inheritance pattern

  • The many combinations tend to average the expression of a given trait

  • As a result, much greater selection pressure is necessary to make genetic progress compared to simple gene inheritance
  •  

     

     

    An example of multiple gene inheritance: Growth Rate

    Growth rate depends upon

  • appetite: which is a function of hypothalamus secretions, size of digestive organs, amount of salivary and gastric secretions, etc. etc.
  • Activity of growth hormones: G-proteins, phosphatases, kinases, etc. etc.
  • Intestinal function which is a result of carrier proteins, cellular efficiency, intestinal motility, etc. etc
  • One could continue this list on and on, just for growth rate
  • Each of these above activities/functions may be controlled by other sub-characteristics thus multiple gene pairs.

     

    Thus to select for greater growth rate (or any other multiple gene trait), you must collectively select for improvement in all genes that code for functions and structures having an impact on that trait.

     

    In some cases, improvement in one function is linked to a setback in another function, thus making overall progress in the desired trait difficult.

     

     

     

    Effect of the Production Environment

    It is often very difficult to separate genetic influences from environmental influences.

    Heritability estimates are efforts to differentiate between those two forces.

    Environmental influences are not transferred to offspring, thus heritibility is only the result of gene transfer.

    Some Common Terms

    Prepotency

  • This is the ability of a parent to transmit its characteristics to its offspring.

  • High prepotency is a function of:
  • Dominant alleles - which ensures the characteristic will be expressed
  • Homozygosity - which ensures that the probability of transferring the dominant gene is high
  •  

    Nicking

  • These are particular matings of a specific Dam and sire which produces outstanding offspring

  • The same animals with other mates do not produce similar results

  • “Well-nicked” matings are the result of complimentary pairing of genes
  • Pure Breeding

    These are matings of animals derived from a common, distinctive ancestor

  • The parents and offspring are more homozygous than non-purebreds

  • Thus they are more prepotent

  • Remember though, prepotent does not necessarily mean superior. It just means these animals will have offspring which are very much like themselves

  • With pure breeding, offspring are either registered or can be registered by the respective breed association
  •  

    Breed Association or Registry

    This is an organization of breeders whose purposes include

  • recording the lineage of animals registered within their breed

  • protecting the purity of the breed

  • promoting interest in the breed
  •  

    Crossbreeding

    Crossbreeding is the mating of animals from different breeds

  • Crossbreeding is the opposite of purebreeding

  • Crossbreeding results in less homozygosity (more heterozygosity) in the offspring

  • Crossbreeding results in greater heterosis (hybrid vigor). For more information on hybrid vigor, please click on HETEROSIS.
  •  

    Inbreeding

    Inbreeding is the mating of animals more closely related than the average population

  • Inbreeding was originally used to develop purebreed foundation animals

  • Inbreeding results in increased homozygosity (and decreased heterosis)

  • Closebreeding = mating of closely related animals (e.g. dam x son, sibling x sibling, etc.)
  • increases homozygosity
  • increases prepotency
  • creates genetically stable line
  • Caution: increases chance of recessive lethals, culls, etc.

  • Linebreeding = matings of more distantly related relatives.
  • Linebreeding is a less intense form of inbreeding than closebreeding
  • It has the same advantages/disadvantages as closebreeding (to lesser degree)

  • Outcrossing = mating of animals within the same breed but having no close ancestral relationships
  • Outcrossing is safer in terms of undesirable traits
  • most purchased purebreds are the result of outcrossing
  •  

    Relative importance of the Boar and Sow

    Boar:

  • The boar contributes to many more matings than any one sow

  • He will have a greater impact on genetic progress than any one sow (why?)

  • Changing boars is a much easier way to change herd genetics
  •  

    Sow:

  • Sows contribute both genetics AND environment for young pig: thus sows have great importance to overall profitability of a swine farm

  • A producer makes a greater long-term commitment when purchasing sows and gilts: That is it is much more difficult financially to change the sow line
  • As far as the pig’s genetics are concerned, each parent provides equal genetic forces.

     

    If you have not yet read the discussion of heterosis, please click here. HETEROSIS